Isavuconazole treatment of a patient with disseminated mucormycosis.

نویسندگان

  • Driele Peixoto
  • Lisa S Gagne
  • Sarah P Hammond
  • Erin T Gilmore
  • Amy C Joyce
  • Robert J Soiffer
  • Francisco M Marty
چکیده

We report a patient with relapsed acute myelogenous leukemia after allogeneic stem cell transplantation who developed disseminated mucormycosis due to Rhizomucor pusillus/R. miehei involving lung, brain, and skin. After failing posaconazole and being intolerant to amphotericin, he was treated effectively with isavuconazole for over 6 months despite ongoing treatment for relapsed leukemia.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Isavuconazole treatment of a patient with disseminated mucormycosis 1 2

Isavuconazole treatment of a patient with disseminated mucormycosis 1 2 Driele Peixoto, MD 3 Lisa S. Gagne, MA 4 Sarah P. Hammond, MD 5 Erin T. Gilmore, MA 6 Amy C. Joyce, NP 7 Robert J. Soiffer, MD 8 Francisco M. Marty, MD 9 10 1 Division of Infectious Diseases, Department of Medicine, Brigham and Women’s Hospital, 11 Boston, Massachusetts, USA. 12 2 Department of Medical Oncology, Dana-Farber...

متن کامل

Breaking the Mold

Objective: To review the current literature for the pathogenesis of mucormycosis, discuss diagnostic strategies, and evaluate the efficacy of polyenes, triazoles, and echinocandins as pharmacological treatment options. Data Sources: An electronic literature search was conducted in PubMed using the MESH terms Rhizopus, zygomycetes, zygomycosis, Mucorales and mucormycosis, with search terms ampho...

متن کامل

Isavuconazole in the treatment of invasive aspergillosis and mucormycosis infections

We have a limited arsenal with which to treat invasive fungal infections caused by Aspergillus and Mucorales. The morbidity and mortality for both pathogens remains high. A triazole antifungal, isavuconazole, was recently granted approval by the US Food and Drug Administration and the European Medicines Agency for the treatment of invasive aspergillosis and mucormycosis. A randomized double-bli...

متن کامل

Role of isavuconazole in the treatment of invasive fungal infections

Despite recent advances in both diagnosis and prevention, the incidence of invasive fungal infections continues to rise. Available antifungal agents to treat invasive fungal infections include polyenes, triazoles, and echinocandins. Unfortunately, individual agents within each class may be limited by spectrum of activity, resistance, lack of oral formulations, significant adverse event profiles...

متن کامل

Isavuconazole as salvage therapy for mucormycosis

Mucormycosis carries a high mortality rate with few therapeutic options available. We describe a man with pulmonary/splenic mucormycosis complicating hypoplastic myelodysplastic syndrome on a background of chronic kidney disease, who achieved a complete response with salvage isavuconazole therapy following intolerance of consecutive courses of liposomal amphotericin and posaconazole therapy.

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of clinical microbiology

دوره 52 3  شماره 

صفحات  -

تاریخ انتشار 2014